The Effect of Support of Zinc and Melatonin on Lipid peroxidation of Various Tissues in Rats with Breast cancer induced by DMBA
Date
2018-10-30Author
GÜLBAHÇE MUTLU, Elif
BALTACI, Saltuk Buğra
MOĞULKOÇ, Rasim
BALTACI, Abdülkerim Kasım
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The aim of the present was study determine the effect of zinc and melatonin supplementation on
lipid peroxidation of various tissues in female rats with breast cancer induced by DMBA (7,12-
Dimethylbenz[a]anthracene). Total 42 Wistar albino female rats were equally separated 5 groups. Group 1
control, Group 2 DMBA control, Group 3 DMBA+Zinc, Group 4 DMBA + Melatonin, Group 5
DMBA+Zinc+Melatonin. Lung, liver, spleen, pancreas and kidney tissue of rats were examined for MDA and
GSH by spectrophotometric. The highest lung, liver, spleen, pancreas and kidney MDA levels were determined
in group 2 (p<0.05). DMBA+Zinc, DMBA+Melatonin and DMBA+Zinc+Melatonin groups have lower MDA
levels compared to group 2 (p<0.05). Similarly, zinc and melatonin supplemented groups (groups 3, 4 and 5)
have higher GSH levels compared to cancer induced group (group 2) (p<0.05). The results of present study
show that increased damage in lung, liver, spleen, pancreas and kidney tissues are inhibited by zinc/melatonin or
zinc+melatonin supplementation. Combine zinc and melatonin supplementation may contribute to preventing of
lipid peroxidation in tumoral conditions.
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