The Effect Of Serum And Follicular Fluid Hypoxia İnducible Factor 1α On İnvitro Fertilization Outcomes İn Patients With Polycystic Ovary Syndrome
Özet
Abstract
Objective: To investigate serum and follicular fluid (FF) HIF-1α levels in nonobese,
nonhyperandrogenic patients with polycystic ovary syndrome (PCOS) undergoing in vitro
fertilization (IVF), in addition to IVF outcomes.
Materials and Methods: A prospective sequential cross-sectional study carried at a Research
and Education Hospital. In total, 160 patients undergoing IVF treatment were included in the
study: 80 patients diagnosed with PCOS according to the Rotterdam criteria (group I, study)
and 80 patients with the etiology of male factor infertility (group II, control).
Results: There were statistically significant between-group differences in serum estradiol (E2)
levels on the day of hCG administration (2,377.00 ± 733.23 versus 1,931.3 ± 1,010.69), the
total gonadotropin dose required (2,000.63 ± 1,051.87 versus 1.134.69 ± 286.45), and the total
number of retrieved oocytes (8.60 ± 2.06 versus 11.05 ± 4.39) (P < 0.05). There was also a
statistically significant between-group difference in serum and FF HIF-1α levels on the day of
oocyte retrieval (0.21 + 0.06 versus 0.17 + 0.04, P = 0.001; 0.09 + 0.05 versus 0.06 + 0.03 P =
0.007; respectively).
Conclusions: In a selected population of nonobese, nonhyperandrogenic PCOS patients, there
was a significant difference in HIF-1α levels of the PCOS group versus those of the control
group. Further studies are needed to determine the effects of HIF-1α in women with PCOS
and to develop a new marker to monitor treatment outcomes.
Koleksiyonlar
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