Acute hypoxia exposure following prenatal stress impairs hippocampus and novelty-seeking behavior in adolescent rats.
Tarih
2022-02-01Yazar
ÇELİK, Kübra
BİLİM, Petek
GARİP, Gurur
DURMAZ, Burak
SÖZMEN, Eser Yıldırım
BAKA, Meral
Üst veri
Tüm öğe kaydını gösterÖzet
Objectives: The present study aimed to investigate the effects of acute hypoxia
exposure following prenatal stress on the novelty-seeking behavior and hippocampus of adolescent rats.
Methods: The offspring were divided into prenatal stress (PS) and non-stress
(NS) groups. Both groups were exposed to hypoxia on postnatal day 10 (P10)
while control groups were undisturbed. Novel object recognition task was performed in each group. Next, brains were collected to examine hippocampus
via immunohistochemical and biochemical studies on postnatal day 35 (P35).
Results: PS decreased novelty discrimination and synaptophysin (SYN)
expressions in both CA1 and CA3 of the hypoxia group prominently
(p < 0.05). Nestin-expressing cells were reduced while vascular endothelial
growth factor (VEGF) expression was enhanced in the subgranular zone (SGZ)
of PS-hypoxia group (p < 0.05). VEGF enhancement triggered angiogenesis in
the CA1 and CA3 significantly (p < 0.05). PS also increased thiobarbituric acid
reactive substances (TBARS) levels in the hypoxia group as a result of oxidative stress (p < 0.05).
Conclusion: These findings demonstrated that PS exacerbates neurodevelopmental deficits in the hippocampus of acute hypoxia-induced
offspring in adolescence.
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