dc.description.abstract | Methylmethane sulfonate (MMS) is an alkylating agent that may react with
DNA and damage it. We investigated histological changes and apoptosis
caused by MMS and the effects of curcumin on MMS treated mouse kidneys.
Twenty-four mice were divided into four equal groups: controls injected
with saline, a group injected with 40 mg/kg MMS, a group injected with
40 mg/kg MMS and given 100 mg/kg curcumin by gavage, and a group given
100 mg/kg curcumin by gavage. MMS caused congestion and vacuole
formation, and elevated the apoptotic index significantly, but had no
other effect on kidney tissue. Curcumin improved the congestion and
vacuole formation caused by MMS and decreased the apoptotic index.
Curcumin administered with MMS appears to decrease the deleterious
effects of MMS on the kidney. | |