Effects of curcumin on methyl methanesulfonate damage to mouse kidney

dc.contributor	CÜCE, Gökhan
dc.contributor	ÇETİNKAYA, Seda
dc.contributor	İŞİTEZ, Nilay
dc.contributor	KÜÇÇÜKTÜRK, Serkan
dc.contributor	SÖZEN, Mehmet Enes
dc.contributor	DEMİREL, Hasan Hüseyin
dc.contributor	KALKAN, Sinan
dc.contributor	CİĞERCİ, İbrahim Hakkı
dc.date.accessioned	2020-08-07T14:18:45Z
dc.date.available	2020-08-07T14:18:45Z
dc.date.issued	2016
dc.identifier	10.3109/10520295.2015.1099737
dc.identifier.issn	1052-0295
dc.identifier.uri	http://hdl.handle.net/20.500.12498/4704
dc.description.abstract	Methylmethane sulfonate (MMS) is an alkylating agent that may react with DNA and damage it. We investigated histological changes and apoptosis caused by MMS and the effects of curcumin on MMS treated mouse kidneys. Twenty-four mice were divided into four equal groups: controls injected with saline, a group injected with 40 mg/kg MMS, a group injected with 40 mg/kg MMS and given 100 mg/kg curcumin by gavage, and a group given 100 mg/kg curcumin by gavage. MMS caused congestion and vacuole formation, and elevated the apoptotic index significantly, but had no other effect on kidney tissue. Curcumin improved the congestion and vacuole formation caused by MMS and decreased the apoptotic index. Curcumin administered with MMS appears to decrease the deleterious effects of MMS on the kidney.
dc.language.iso	English
dc.publisher	Taylor \& Francis Ltd
dc.source	Biotechnic \& Histochemistry
dc.title	Effects of curcumin on methyl methanesulfonate damage to mouse kidney
dc.type	Makale